^aDepartment of Chemistry, Hazara University Mansehra, KPK, Pakistan

^bDepartment of Chemistry, COMSATS University Islamabad, Abbottabad campus KPK, Pakistan

c Co-pionneer of Spectro-Fluor TM (aka Carbone-Fluorine Spectroscopy,

Fluorotronics USA, Inc. San Diego, CA, USA

^dDepartment of Chemistry, University of Azad Jammu and Kashmir,

Muzaffarabad, 13100 Pakistan

Sodium alginate and PVP clay reinforced nanocomposites films were prepared by applying solvent casting technique using aqueous solution. The chemical behaviour and external morphology of nanocomposites films were studied by TGA, XRD, SEM, EDX and EDX Mapping technique. The pharmaceutical study was carried out by swelling study, erosion study. Ex-vivo permeate on study and dissolution study. The TGA study revealed the high miscibility between sodium alginate and PVP blends. The addition of MMT in blends convert crude surface of the films into interlinked porous state. The thermal stability, crystallinity, tensile and mechanical strength of blends has also increased by addition of MMT and drug.EDX and EDX mapping technology confirmed the consistency in mixing components and their equivalent distribution. The swelling and erosion attitude of films increases in the presence of PVP. The results of in vitro permeation study via rat skin and dissolution study showed the successful application of drug loaded formulations for sustained and targeted drug delivery. The different rate of drug release from formulation at pH 1.2, pH 4.5 and pH 6.8 showed that the drug release is directed by PH. The sodium alginate and pvp based biopolymer nanocomposites films would be able for continual discharge of drug ceftriaxone.