^aMedical Engineering Department, Faculty of Engineering, Al-Ahliyya Amman University, Amman, 19328, Jordan

^bMedical Engineering Department, Faculty of Engineering, Al-Ahliyya Amman University, Amman, 19328, Jordan

c Civil Engineering Department, Faculty of Engineering, Al-Ahliyya Amman University, Amman, 19328, Jordan

An emerging field of tissue engineering combines medical, biological, and engineering principles to produce tissue-engineered constructs that regenerate, preserve, or slightly enhance the functions of natural tissue. By creating structures that replicate the extracellular matrix, oxygen and nutrients will be transmitted more effectively while releasing toxins during tissue repair, all while creating mature tissues. Three-dimensional nanostructures for tissue engineering have been the focus of numerous studies over the last few years. Electrospinning is a highly effective technique in this category. The last few decades, numerous nanofibrous scaffolds have been developed for tissue repair and restoration. Nanofibrous meshes as tissue engineered scaffolds for various tissues, such as neural, cardiovascular, skin, cartilage, and tendon are discussed in this article. In addition, the current article discusses recent advancements in tissue regeneration as well as challenges associated with electrospinning.