^aDepartment of Physics, Govt. Arts College (Autonomous), Salem - 636007, Tamil Nadu, India

^bDepartment of Physics, Govt. Arts College for Women, Salem - 636008, Tamil

Nadu, India

c UNESCO-UNISA, Africa Chair in Nanosciences/Nanotechnology Laboratories,

College of Graduate Studies, University of South Africa (UNISA), Muckleneuk

Ridge, PO Box 392, Pretoria, South Africa

^dNanosciences African Network (NANOAFNET), Materials Research Group

(MRG), iThemba LABS-National Research Foundation (NRF), 1 Old Faure Road, 7129, PO Box 722, Somerset West, Western Cape Province, South Africa

This study presents a synthesis of copper nanoparticles in which an intermediate aqueous extract of the leaves of Andrographis paniculata. The synthesis copper nanoparticles (CuNPs) was supervised by UV-visible spectroscopy at room temperature. FTIR analysis prepared nanoparticles exhibited the attendance of comparable peaks established in the leaves extract spectra. XRD analysis inveterate the crystalline structure of synthetic copper nanoparticles. SEM's images presented that greatest balls were a spherical, like a shaped one. Subsequently, CuNPs was further analyzed for anti-bacterial effects from the Gram positive and Gram negative was obviously detected.