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1 Department of Chemistry and Environmental Science, Madan Mohan Malaviya University of Technology, Gorakhpur-273010, U.P., India,
2 Department of Physics and Material Science, Madan Mohan Malaviya University of Technology, Gorakhpur-273010, U.P., India
3 Department of Physical Sciences Starex University Delhi-NCR Gurugram
*Correspondence: rajeshkr_yadav2003@yahoo.co.in
Journal of Ovonic Research 2026, 22(3),171-184; https://doi.org/10.67229/JOR16632
The efficient and selective regeneration of nicotinamide adenine dinucleotide (NADH) remains a significant challenge in biocatalysis due to the limited availability of sustainable and metal-free photocatalytic systems. Herein, we report a novel metal-free photocatalytic strategy that integrates boron- and selenium-doped graphitic carbon nitride (B–Se–g-C₃N₄) with Eosin B (EB) as a synergistic photosensitizer for highly selective NADH regeneration. The novelty lies in the rational combination of heteroatom co-doping (B and Se) with an organic dye to enhance charge separation and selectively promote 1,4-NADH under irradiation. The developed system exhibits a high photo-regeneration efficiency of 95.83% with excellent selectivity toward the biologically active 1,4-NADH isomer. This approach not only expands the scope of dye-assisted, metal-free photocatalysis but also establishes a sustainable and efficient platform for cofactor regeneration, advancing green chemistry and biocatalytic applications.
